Dr. Shang-Te Danny Hsu is a structural biologist whose research focuses on elucidating how post-translational modifications (PTMs) such as glycosylation and ubiquitination regulate protein structure, dynamics, and activity. His laboratory integrates high-resolution NMR spectroscopy, cryo-electron microscopy, and mass spectrometry with AI-assisted modeling to uncover the molecular principles governing protein regulation. By emphasizing functional annotation of structure–activity relationships, Dr. Hsu’s group seeks to define how specific PTM patterns influence molecular recognition, stability, and signaling outcomes. Through the development of new analytical workflows and computational tools, his team advances the capacity to interpret conformational and compositional heterogeneity in complex protein systems. Collectively, these efforts aim to establish a quantitative framework linking chemical modifications to biological function, providing mechanistic insight into the dynamic regulation of cellular processes and laying the foundation for structure-guided approaches to disease intervention.